Three hundred six and 386 (55.2%) patients received hydroxocobalamin. ResultsĪmong 854 patients screened, 739 patients were included. We assessed the risk of AKI (primary endpoint), severe AKI, major adverse kidney (MAKE) events, and survival (secondary endpoints) after administration of hydroxocobalamin using logistic regression models. We excluded patients discharged at home alive within 24 h of admission. We included patients admitted to an ICU for smoke inhalation between January 2011 and December 2017. We conducted a multicenter retrospective study in 21 intensive care units (ICUs) in France. The impact of hydroxocobalamin on the risk of acute kidney injury (AKI) and survival after smoke inhalation in a multicenter setting remains unexplored. ![]() ![]() Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study. The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study
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